Bradford Scholars is the University of Bradford online research archive. Access is free to anyone interested in research being conducted at Bradford. In the repository you will find a range of materials from journal articles and conference papers to research reports and theses.

Contact the repository team via [email protected] with any queries about Open Access or to deposit your research papers.

 


 

Shown below is a list of communities and the collections and sub-communities within them. Click on a name to view that community or collection home page.

  • Emergency Department Pharmacist Practitioners: A new role in the NHS

    Greenwood, D.; Tully, M.P.; Martin, Sandra J.; Steinke, D. (2018)
  • Development of an Emergency Department Pharmacist Practitioner service specification

    Greenwood, D.; Steinke, D.; Martin, Sandra J.; Tully, M. (2018)
  • Can contrast-response functions indicate visual processing levels?

    Breitmeyer, B.G.; Tripathy, Srimant P.; Brown, J.M. (2018-03-01)
    Many visual effects are believed to be processed at several functional and anatomical levels of cortical processing. Determining if and how the levels contribute differentially to these effects is a leading problem in visual perception and visual neuroscience. We review and analyze a combination of extant psychophysical findings in the context of neurophysiological and brain-imaging results. Specifically using findings relating to visual illusions, crowding, and masking as exemplary cases, we develop a theoretical rationale for showing how relative levels of cortical processing contributing to these effects can already be deduced from the psychophysically determined functions relating respectively the illusory, crowding and masking strengths to the contrast of the illusion inducers, of the flankers producing the crowding, and of the mask. The wider implications of this rationale show how it can help to settle or clarify theoretical and interpretive inconsistencies and how it can further psychophysical, brain-recording and brain-imaging research geared to explore the relative functional and cortical levels at which conscious and unconscious processing of visual information occur. Our approach also allows us to make some specific predictions for future studies, whose results will provide empirical tests of its validity.
  • Bottlenecks of motion processing during a visual glance: the leaky flask model

    Ögmen, H.; Ekiz, O.; Huynh, D.; Bedell, H.E.; Tripathy, Srimant P. (2013-12-31)
    Where do the bottlenecks for information and attention lie when our visual system processes incoming stimuli? The human visual system encodes the incoming stimulus and transfers its contents into three major memory systems with increasing time scales, viz., sensory (or iconic) memory, visual short-term memory (VSTM), and long-term memory (LTM). It is commonly believed that the major bottleneck of information processing resides in VSTM. In contrast to this view, we show major bottlenecks for motion processing prior to VSTM. In the first experiment, we examined bottlenecks at the stimulus encoding stage through a partial-report technique by delivering the cue immediately at the end of the stimulus presentation. In the second experiment, we varied the cue delay to investigate sensory memory and VSTM. Performance decayed exponentially as a function of cue delay and we used the time-constant of the exponential-decay to demarcate sensory memory from VSTM. We then decomposed performance in terms of quality and quantity measures to analyze bottlenecks along these dimensions. In terms of the quality of information, two thirds to three quarters of the motion-processing bottleneck occurs in stimulus encoding rather than memory stages. In terms of the quantity of information, the motion-processing bottleneck is distributed, with the stimulus-encoding stage accounting for one third of the bottleneck. The bottleneck for the stimulus-encoding stage is dominated by the selection compared to the filtering function of attention. We also found that the filtering function of attention is operating mainly at the sensory memory stage in a specific manner, i.e., influencing only quantity and sparing quality. These results provide a novel and more complete understanding of information processing and storage bottlenecks for motion processing.
  • β‐Ketoiminato Iridium(III) Organometallic Complexes: Selective Cytotoxicity towards Colorectal Cancer Cells HCT116 p53‐/‐

    Lord, Rianne M.; Zegke, Markus; Henderson, I.R.; Pask, C.M.; Shepherd, H.J.; McGowan, P.C. (2019-01-07)
    This report presents a new library of organometallic iridium(III) compounds of the type [Cp*IrCl(L)] (Cp*=pentamethylcyclopentadienyl and L=a functionalized β‐ketoiminato ligand) showing moderate to high cytotoxicity against a range of cancer cell lines. All compounds show increased activity towards colorectal cancer, with preferential activity observed against the immortalized p53‐null colorectal cell line, HCT116 p53‐/‐, with sensitivity factors (SF) up to 26.7. Additionally, the compounds have excellent selectivity for cancerous cells when tested against normal cell types, with selectivity ratios (SR) up to 35.6, contrary to that of cisplatin, which is neither selective nor specific for cancerous cells (SF=0.43 and SR=0.7–2.3). This work provides a preliminary understanding of the cytotoxicity of iridium compounds in the absence of p53 and has potential applications in treatment of cancers for which the p53 gene is absent or mutant.

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